Synchrotron Radiation Infrared and Raman Spectroscopy for Biomedical Applications
نویسندگان
چکیده
Over the last few decades, infrared (IR) spectroscopy has been recognized as a useful tool to obtain quantitative and qualitative information on IR active materials and bio-materials, with particular emphasis to polymer chemistry and organic chemistry. Nowadays, thanks to technological evolution, the possibilities offered by vibrational spectroscopy (e.g. IR and Raman spectroscopy) are much broader, the most promising being strongly connected to modern medicine demands in clinical and laboratory diagnosis. The scientific base of these techniques relies on measurement of the natural vibrational frequencies of the atomic bonds in molecules, which mainly depends on structural parameters. The aim of this chapter is to describe the state of the art of Synchrotron Radiation Fourier Transform Infrared spectroscopy (SR-FTIR) and Raman micro-spectroscopy applied to biomedical samples (e.g. in-vivo and ex-vivo studies on human tissues and tumor cells). For completeness, sample preparation and other complementary techniques are presented.
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